2025
Multi-omic identification of perineurial hyperplasia
and lipid-associated nerve macrophages in human polyneuropathies.
Heming M, Börsch AL, Wolbert J, Thomas C, Mausberg AK, Szepanowski F, Eggert B, Lu IN, Tietz J, Dienhart F, Meschnark M,
Strecker JK, Glatza M, Thomas C, Gmahl N, Dambietz C, Müther M, Uerschels AK, Keyvani K, Minnerup J, Doppler K, Üçeyler N, Aprea J, Dahl A, Stassart R, Fledrich R, Wiendl H,
Sommer C, Stettner M, Meyer zu Hörste G.
Nature Communications. 2025 Aug 23;16(1):7872. doi: 10.1038/s41467-025-62964-8
Hypoxia-induced conversion of sensory Schwann cells into repair
cells is regulated by HDAC8.
Hertzog N, Duman M, Bochud M, Brügger-Verdon V, Gerhards M, Schön F, Dorndecker F, Meijer D, Fledrich R,
Stassart R, Sankar DS, Dengjel J, López SR, Jacob C.
Nature Communications. 2025 Jan 9;16(1):515. doi: 10.1038/s41467-025-55835-9
2024
Myelinated peripheral axons are
more vulnerable to mechanical trauma in a model of enlarged axonal diameters.
Gargareta VI, Berghoff SA, Krauter D, Hümmert S, Marshall-Phelps KLH, Möbius W, Nave KA, Fledrich R, Werner HB,
Eichel-Vogel MA. Glia. 2024 Sep;72(9):1572-1589. doi: 10.1002/glia.24568.
Targeting PI3K/Akt/mTOR signaling
in rodent models of PMP22 gene-dosage diseases.
Krauter D, Stausberg D, Hartmann TJ, Kungl T, Rasche DA, Saher G, Fledrich R, Stassart RM, Nave KA, Goebbels S,
Ewers D, Sereda MW. EMBO Molecular Medicine. 2024 Mar;16(3):616-640. doi: 10.1038/s44321-023-00019-5.
2023
Adipo-glial signaling mediates
metabolic adaptation in peripheral nerve regeneration.
Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA,
Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G,
Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM#, Fledrich R#.
Cell Metabolism. 2023 Dec 5;35(12):2136-2152.e9. doi: 10.1016/j.cmet.2023.10.017
Myelin insulation as a risk factor for axonal
degeneration in autoimmune demyelinating disease.
Schäffner E*, Bosch-Queralt M*, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff
SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich
R#, Nave KA#, Stassart RM#.
Nature Neuroscience. 2023 Jul;26(7):1218-1228. doi: 10.1038/s41593-023-01366-9
2022
Schwann cell functions in peripheral nerve
development and repair.
Bosch-Queralt M, Fledrich R*, Stassart RM*.
Neurobiology of Disease. 2023 Jan;176:105952. doi: 10.1016/j.nbd.2022.105952
Targeted inactivation
of the Septin2 and Septin9 genes in myelinating Schwann cells of mice.
Martens AK, Erwig M, Patzig J, Fledrich R, Füchtbauer EM, Werner HB.
Cytoskeleton (Hoboken). 2022 Nov 15. doi: 10.1002/cm.21736
Early targeting of endoneurial macrophages
alleviates the neuropathy and affects abnormal Schwann cell differentiation in a mouse model of Charcot-Marie-Tooth 1A.
Klein D, Groh J, Yuan X, Berve K, Stassart R, Fledrich R, Martini R.
Glia. 2022 Jun;70(6):1100-1116. doi: 10.1002/glia.24158.
2021
AAV2/9-mediated silencing of PMP22 prevents
pathological features in a rat model of Charcot-Marie-Tooth disease 1 A.
Gautier B*, Hajjar H, Soares S, Berthelot J, Deck M, Abbou S, Campbell G, Ceprian M, Gonzalez S, Fovet CM, Schütza
V, Jouvenel A, Rivat C, Zerah M, François V, Le Guiner C, Aubourg P, Fledrich R*, Tricaud N*.
Nature Communications. 2021 Apr 21;12(1):2356. doi: 10.1038/s41467-021-22593-3
Hyperactivity is a Core Endophenotype of Elevated Neuregulin-1 Signaling in Embryonic Glutamatergic Networks.
Götze T, Soto-Bernardini MC, Zhang M, Mießner H, Linhoff L, Brzózka MM, Velanac V, Dullin C, Ramos-Gomes F, Peng M,
Husseini H, Schifferdecker E, Fledrich R, Sereda MW, Willig K, Alves F, Rossner MJ, Nave KA, Zhang W, Schwab MH.
Schizophrenia Bulletin. 2021 Apr 19:sbab027. doi: 10.1093/schbul/sbab027
2020
CMTM6 expressed on the adaxonal Schwann cell surface
restricts axonal diameters in peripheral nerves.
Eichel MA, Gargareta VI, D'Este E, Fledrich R, Kungl T, Buscham TJ, Lüders KA, Miracle C,
Jung RB, Distler U, Kusch K, Möbius W, Hülsmann S, Tenzer S, Nave KA, Werner HB.
Nature Communications. 2020 Sep 9;11(1):4514. doi: 10.1038/s41467-020-18172-7.
Redefining the heterogeneity of peripheral
nerve cells in health and autoimmunity.
Wolbert J, Li X, Heming M, Mausberg AK, Akkermann D, Frydrychowicz C, Fledrich R, Groeneweg L, Schulz C, Stettner M, Alonso Gonzalez N,
Wiendl H, Stassart R, Meyer Zu Hörste G.
Proc Natl Acad Sci U S A. 2020 Apr
28;117(17):9466-9476. doi: 10.1073/pnas.1912139117. Epub 2020 Apr 15.
Proteome profile of peripheral myelin in healthy mice and in a
neuropathy model.
Siems SB, Jahn O, Eichel MA, Kannaiyan N, Wu LMN, Sherman DL, Kusch K, Hesse D, Jung RB, Fledrich R, Sereda MW, Rossner MJ, Brophy PJ,
Werner HB.
Elife. 2020 Mar 4;9. pii: e51406. doi: 10.7554/eLife.51406.
2019
Axo-glial interdependence in peripheral nerve development.
Fledrich R*, Kungl T, Nave KA, Stassart RM*.
Development. 2019 Nov 12;146(21). pii: dev151704. doi: 10.1242/dev.151704. Review.
Neuregulin-1 type I dependent
autoparacrine stimulation of Schwann cells in peripheral neuropathies.
Fledrich R*, Akkermann D*, Abdelaal T, Schütza V, Hermes D, Schäffner E, Soto-Bernardini
MC, Götze T, Klink A, Kusch K, Krueger M, Kungl T, Frydrychowicz C, Möbius W, Brück W, Müller WC, Bechmann I, Sereda MW, Schwab MH, Nave KA, Stassart RM
Nature Communications. 2019, Apr 1;10(1):1467. doi: 10.1038/s41467-019-09385-6
recommended at F1000
Myelinating Glia-Specific Deletion of
Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy.
Joseph S, Vingill S, Jahn O, Fledrich R, Werner HB, Katona I, Möbius W, Mitkovski M, Huang Y, Weis J, Sereda MW, Schulz JB, Nave KA,
Stegmüller J.
J Neurosci. 2019 Jul 10;39(28):5606-5626. doi: 10.1523/JNEUROSCI.3094-18.2019.
2018
Targeting myelin lipid metabolism as a
potential therapeutic strategy in a model of CMT1A neuropathy.
Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU,
Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM* and Sereda MW*
Nature Communications. 2018, Aug 2;9(1):3025. doi: 10.1038/s41467-018-05420-0
2017
Biomarkers
predict outcome in Charcot-Marie-Tooth disease 1A.
Fledrich R, Mannil M, Leha A, Ehbrecht C, Solari A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Schnizer TJ, Prukop T,
Garcia-Angarita N, Czesnik D, Haberlová J, Mazanec R, Paulus W, Beissbarth T, Walter MC, TRIAAL, Hogrel JY, Dubourg O, Schenone A, Baets J, De Jonghe P, Shy ME, Horvath R, Pareyson D, Seeman P,
Young P, Sereda MW
Journal of Neurology, Neurosurgery and Psychiatry 2017 Nov; 88(11):941-952. doi: 10.1136/jnnp-2017-315721
recommended at F1000
2016
Proteolipid
protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.
Patzig J, Kusch K, Fledrich R, Eichel MA, Lüders KA,
Möbius W, Sereda MW, Nave KA, Martini R, Werner HB.
Glia. 2016 Jan;64(1):155-74. doi: 10.1002/glia.22922
2014
Fledrich R*, Stassart RM*, Klink A, Rasch LM, Prukop T, Haag L, Czesnik D, Kungl T, Abdelaal TA, Keric N,
Stadelmann C, Brück W, Nave KA, Sereda MW.
Nature Medicine. 2014 Sep;20(9):1055-61. doi: 10.1038/nm.3664. Epub 2014 Aug 24.
Progesterone antagonist therapy in a
Pelizaeus-Merzbacher mouse model.
Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW.
Am J Hum Genet. 2014 Apr 3;94(4):533-46. doi: 10.1016/j.ajhg.2014.03.001. Epub 2014 Mar
27
2013
A role for Schwann cell-derived
neuregulin-1 in remyelination.
Stassart RM*, Fledrich R*, Velanac V, Brinkmann BG, Schwab MH, Meijer D, Sereda MW, Nave KA.
Nature Neuroscience. 2013 Jan;16(1):48-54. doi: 10.1038/nn.3281. Epub 2012 Dec 9.
recommended at F1000
2012
Murine therapeutic models for
Charcot-Marie-Tooth (CMT) disease.
Fledrich R, Stassart RM, Sereda MW.
British Medical Bulletin. 2012 Jun;102:89-113. doi: 10.1093/bmb/lds010. Epub 2012 May 2.
Review.
Lithium enhances remyelination of
peripheral nerves.
Makoukji J, Belle M, Meffre D, Stassart RM, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F,
Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C.
Proceedings of the National Academy of Science, U
S A. 2012 Mar 6;109(10):3973-8. doi: 10.1073/pnas.1121367109.
recommended at F1000
A rat model of
Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients.
Fledrich R, Schlotter-Weigel B, Schnizer TJ, Wichert SP, Stassart RM, Meyer zu Hörste G, Klink A, Weiss
BG, Haag U, Walter MC, Rautenstrauss B, Paulus W, Rossner MJ, Sereda MW.
Brain. 2012 Jan;135(Pt 1):72-87. doi: 10.1093/brain/awr322. Epub 2011 Dec 20.
2011
Sodium-dependent vitamin C
transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system.
Gess B, Röhr D, Fledrich R, Sereda MW, Kleffner I, Humberg A, Nowitzki J, Strecker JK, Halfter H, Young P.
Journal of Neuroscience. 2011 Nov
23;31(47):17180-92. doi: 10.1523/JNEUROSCI.3457-11.2011.
The
Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.
Meyer zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW.
Neurobiol Dis. 2011 Apr;42(1):1-8. doi: 10.1016/j.nbd.2010.12.006. Epub 2010 Dec 16.
